UK Salengei ACTIVE DETOX

The
liver detoxifying process consists of a chain of enzymatic reactions
that transform undesirable chemicals into substances that are easily
eliminated through the urine or faeces. These compounds have to go
through enzymatic processes divided into two stages: Phase I and Phase II.

Phase I is an ACTIVATION stage
during which toxins or chemicals are transformed into more active
intermediary types, therefore more toxic, such as the formation of free
radicals that damage cells and DNA. This first stage needs the support
of certain antioxidants and other components capable of inhibiting the
pro-activation of such carcinogens.

Phase II is a BIOINACTIVATION=DETOXIFYING stage
which reduces the molecule’s toxic effect through its conjugation with
certain components that facilitate the solubility of the toxic compound,
and thus its elimination via the urine and faeces. A slight inhibition
of Phase I enzymes together with an induction of Phase II enzymes is
considered the basis of preventive treatments.

Chlorella is a unicellular micro algae that measures
from two to ten micron and whose molecular structure enables it to bond
to heavy metals, pesticides and chemicals, facilitating their
elimination. A good source of proteins (about 58 percent of its
composition), it is very rich in amino acids such as glutamic acid (one
of the main ones), which is essential for the synthesis of glutathione, a
tripeptide that functions directly on Phase II of detoxification.

Cysteine is an amino acid with a thiol group, which
is susceptible to oxidization due to its ability to undergo redox
reactions, giving cysteine antioxidant properties. Together with glycine
and glutamic acid, it is essential for glutathione (GSH) biosynthesis.
Glutamic acid and glycine are easily available in most western diets,
but the availability of cysteine can be the limiting substrate.

The thiol group also has a high affinity for heavy metals, thus
making cysteine-containing proteins such as metallothionein bind metals
like mercury, lead and cadmium tightly.

As well as being essential for the biosynthesis of glutathione, glycin and cysteine are
also necessary for the elimination of bile acid. Furthermore, cysteine
is required for the process of sulfation, but sometimes sulfation is not
efficient enough, which is why taurine facilitates conjugation for the
elimination of sulfates (SO⁴) via the urine.

Glycine is also involved in the elimination of benzoates (food preservatives).

Alpha lipoic acid acts as a potent antioxidant that
regenerates other antioxidants like vitamin C, vitamin E and reduced
glutathione. It also has metal-chelating properties.

Milk thistle. The medicinal components of milk
thistle are the seeds or fruits. When the fruit ripens it contains three
powerful plant elements collectively called silymarin which help the
liver in three ways:

• It is a potent antioxidant that protects the liver (and possibly other organs) against harmful oxidation
• It protects it against toxins and helps in cases of hepatitis B and C
• It acts against fatty liver disease (often caused by excessive
  alcohol intake), and protects against certain medications that damage
  the liver when taken for long periods of time.

Turmeric acts as an antioxidant, anti-inflammatory
and hepatoprotector, and has similar detoxifying properties to milk
thistle. Turmeric can help with disorders such as cirrhosis and fatty
liver, as well as reduce hepatic lesions caused by chemicals and
medicines. It has potential to improve biliary function.

Resveratrol helps mainly as an inhibitor of proactivation of Phase I carcinogens.

Lycopene helps in the process of detoxification of
Phase II via nuclear factor E2 (Nrf2), a key factor of cellular response
to oxidative stress of cells and other tissues. The buildup of nuclear
Nrf2 activates target genes of Phase II antioxidants’ enzymes, such as
GST and GSH.

Selenomethionine is an essential trace element. The
selenide ion forms a very stable compound, insoluble with mercury, and
provides relief of mercurialism symptoms. It can also be incorporated
with organic molecules, and mercury’s organic selenium complexes can be
transported through membranes. The detoxifying process can also deplete
selenium-dependent enzymes such as glutathione peroxidase.

Zinc plays an important detoxifying and antioxidant role as an SOD (superoxide dismutase) co-factor.